研究人员开发出一种新型可穿戴生物传感隐形眼镜，能够通过测量泪液中的神经递质血清素来评估人体压力水平1。这款隐形眼镜采用柔性水凝胶材料封装石墨烯和银电极，检测灵敏度极高，可感知低至72皮摩尔/升的血清素浓度1。
隐形眼镜的耐久性已得到验证，可承受超过28天的反复翻转、折叠、拉伸和扭转1。研究团队在人类志愿者身上进行了测试，发现在公开演讲和数学挑战后，志愿者泪液中的血清素水平出现下降1。动物实验方面，研究人员在麻醉小猪的眼睛上进行了5分钟的测试，未观察到感染或刺激迹象1。
来自Terasaki生物医学创新研究所的研究团队表示，"眼泪可能成为实用的非侵入性生化信息来源，可随时间重复测量"1。这项研究于2023年9月16日发表在《Science Translational Medicine》期刊上1，有望为非侵入式持续监测生化指标的可穿戴平台应用开辟新的方向。
Researchers have developed an innovative contact lens capable of assessing stress by measuring serotonin, a neurotransmitter, in tears.1 The device incorporates a flexible hydrogel material that encases graphene and silver electrodes, enabling detection of serotonin at exceptionally low concentrations of 72 picomoles per liter—below the average serotonin level found in human tears at 15 nanomoles per liter.1 The technology has been validated through experiments involving human volunteers and animal models, positioning it as a promising non-invasive wearable platform for continuous monitoring of biochemical markers.1
The contact lens demonstrated remarkable durability, withstanding more than 28 days of repeated flipping, folding, stretching, and twisting.1 Testing with human volunteers revealed that serotonin levels declined following stressful activities such as public speaking and mathematical challenges.1 In animal trials, researchers conducted five-minute tests on the eyes of anesthetized pigs with no signs of infection or irritation observed.1 Yangzhi Zhu, a researcher involved in the project, noted that "tears could become a practical source of non-invasive biochemical information that can be repeatedly measured over time."1 The findings were published on September 16, 2023, in Science Translational Medicine.1
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