冷泉港实验室研究人员发现，当视觉信息产生矛盾时，大脑的不同视觉区域会通过一种"共识建立"机制来化解冲突1。这项研究由Mitra Javadzadeh领导，联合剑桥大学和伦敦大学学院的团队合作完成1。研究表明，初级视觉皮层（V1）和侧内侧视觉区（LM）这两个相邻脑区在处理同一场景时，当两个脑区的活动相匹配时，相关信号会保持，而冲突信号则会在几分之一秒内迅速消退1。
研究人员通过训练小鼠区分两种相反方向倾斜的视觉图案，并通过临时沉默V1或LM来观察其行为变化1。这一发现揭示了大脑如何将多个专业化输入整合为统一的世界观1。该研究已发表在《自然神经科学》期刊上1。
Researchers at Cold Spring Harbor Laboratory have discovered a remarkable mechanism by which the brain reconciles conflicting visual information from different cortical regions. When the visual cortex processes a scene, specialized areas that normally handle distinct aspects of what we see must sometimes work with contradictory signals.1 The study, led by Mitra Javadzadeh, Cynthia R. Stebbins Fellow at Cold Spring Harbor Laboratory, and conducted in collaboration with researchers from Cambridge University and University College London, found that adjacent brain regions achieve agreement through a process of consensus-building that rapidly suppresses conflicting inputs.1
The research focused on two neighboring regions in the visual cortex: V1, the primary visual cortex, and LM, the lateral medial visual area.1 Scientists trained mice to distinguish between visual patterns tilted in opposite directions and observed how these two brain regions coordinated their activity.1 When signals from both areas aligned, the neural activity persisted and enabled consistent perception; however, when the regions produced conflicting signals, these discordant inputs were rapidly extinguished within fractions of a second.1 By temporarily silencing either V1 or LM during experiments, researchers documented how this dynamic interplay between brain regions shapes visual perception and allows the brain to construct a unified understanding of the world from multiple specialized sensory inputs.1
The findings, published in Nature Neuroscience on September 24, 2026, reveal how the brain integrates diverse cortical signals into a coherent visual experience.1
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