Anthropic的生命科学研究组利用Claude AI在DNA序列数据库中自主发现了一种新型酶系统，命名为阵列相关逆转录酶（ART）1。该系统具有类似CRISPR的重复序列特征，主要存在于噬菌体中，由逆转录酶、伴生基因和重复DNA序列阵列三部分组成1。
Claude通过搜索超过20万个逆转录酶完成了这一发现1。在花费21小时、动员约950个代理使用2.1亿个token的搜索过程中，Claude从这些逆转录酶中筛选出3,500个新候选系统，最终确定了20个最有说服力的候选1。MIT和Broad Institute的CRISPR先驱Feng Zhang对这一发现评价称："这是一个令人兴奋的例子，展示了AI代理如何能对生物学发现做出贡献"1。
Anthropic于2026年春季成立这一生命科学研究组，目标是利用通用AI模型系统化和加速生物学发现1。
Anthropic's newly established life sciences research group has announced the autonomous discovery of a previously unknown enzyme system through Claude AI, marking a significant milestone in computational biology. The system, designated Array-Associated Reverse Transcriptases (ART), exhibits repeating DNA sequences similar to those found in CRISPR technology 1. Claude identified this breakthrough by systematically searching through a database of over 200,000 reverse transcriptases, narrowing the field to 3,500 candidate systems and ultimately isolating 20 of the most compelling candidates within 21 hours of computational analysis 1.
The discovery process required approximately 950 agent uses and the processing of 210 million tokens to complete 1. The ART system, predominantly found in bacteriophages, comprises three functional components: reverse transcriptases, associated genes, and arrays of repetitive DNA sequences 1. Feng Zhang, a CRISPR pioneer from MIT and the Broad Institute, characterized the finding as demonstrating "an exciting example of how AI agents can contribute to biological discovery" 1. Anthropic established this research division in spring 2026 with the explicit goal of leveraging general-purpose AI models to systematize and accelerate biological research discoveries 1.
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