干细胞移植成功逆转小鼠中风损伤并恢复运动能力

苏黎世大学研究人员通过向中风小鼠脑部移植人类神经干细胞，成功逆转了中风导致的运动障碍。1 研究表明，移植后的干细胞在五周内保持较高存活率，大部分细胞分化为神经元并与现有脑细胞建立通信。1 值得注意的是，延迟一周后进行干细胞移植比立即治疗的效果更为显著。1

神经干细胞的治疗作用不仅限于生成新的神经元。1 研究发现，这些移植的干细胞还能诱导血管新生、减少炎症反应、改善血脑屏障的完整性。1 研究团队运用人工智能辅助分析，验证了干细胞移植在逆转中风损伤中的有效性。1 该研究采用了不含动物成分的干细胞生产工艺，并与京都大学诱导多能干细胞研究应用中心开展合作。1

这项成果已发表在2025年《自然通讯》期刊上，为未来人类脑卒中再生治疗提供了科学依据。临床应用前仍需要解决包括安全风险在内的多项障碍。1

Researchers at the University of Zurich have demonstrated that transplanting human neural stem cells into the brains of stroke-affected mice successfully promotes the generation of new neurons and restores motor function 1. The transplanted stem cells showed high survival rates within five weeks after implantation, with the majority differentiating into neurons that communicate with existing brain cells 1. Beyond neurogenesis, the transplanted cells induced blood vessel formation, reduced inflammation, and improved blood-brain barrier integrity 1.

A key finding from the research is that delaying stem cell treatment by one week after stroke yields better outcomes than immediate transplantation 1. Using artificial intelligence-assisted analysis, the team confirmed that stem cell transplantation reversed the motor deficits caused by stroke 1. The research employed an animal-component-free stem cell production process developed in collaboration with Kyoto University's Center for iPS Cell Research and Application 1. The findings, published in Nature Communications in 2025 with DOI 10.1038/s41467-025-63725-3, offer promise for future regenerative therapies in human stroke recovery, though clinical translation will require addressing multiple safety concerns and other barriers 1.