华盛顿大学医学院圣路易斯分校的研究人员在颅骨骨髓中发现了一个隐藏的淋巴结样免疫结构，可作为对抗脑癌的快速应对防线。1该研究由病理学与免疫学杰出教授Jonathan Kipnis博士领导，博士后研究员Jang Hyun Park为第一作者，已于2026年发表在《自然》杂志上。1
研究使用小鼠胶质母细胞瘤模型进行实验，在颅骨骨髓内发现了组织化的免疫结构，其特征与正常淋巴结中的结构相似。1在随后的治疗实验中，研究人员在头皮下放置含有三种免疫刺激蛋白的凝胶，结果显示接受治疗的小鼠对肿瘤的排斥效应更加有效，存活时间也显著延长。1此外，研究人员在人类颅骨骨髓中也发现了类似的免疫细胞。1研究表明，强化这一本地免疫防御机制可以改善肿瘤排斥和存活率，为针对颅骨的新型脑癌治疗策略开辟了可能性。1
Researchers at Washington University School of Medicine in St. Louis have discovered a hidden lymph node-like immune structure within the bone marrow of the skull that functions as a rapid-response defense against brain cancer.1 Led by Dr. Jonathan Kipnis, the Alan A. and Edith L. Wolff Distinguished Professor of Pathology & Immunology, the team identified organized immune structures within cranial bone marrow that resemble those found in normal lymph nodes.1 Similar immune cells have also been detected in human cranial bone marrow, suggesting the mechanism may translate across species.1
In experiments using a mouse glioblastoma model, the researchers tested a therapeutic approach by placing a gel containing three immune-stimulating proteins under the scalp.1 Mice receiving this treatment showed more effective tumor rejection and longer survival times compared to controls.1 The findings, published in Nature in 2026, suggest that strengthening this localized immune defense could improve tumor rejection and survival rates.1 The discovery opens new possibilities for developing brain cancer treatments targeting the skull's immune capabilities.1
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