斯坦福大学神经科学家Sergiu Pașca团队在《自然》杂志报告了一项研究：通过遗传工程改造小鼠使其脑皮层和海马体缺失，随后注入人类脑类器官，成功使近一半的小鼠脑体积被人类细胞替代1。含有人类脑细胞的小鼠在迷宫测试中表现更好，而缺乏脑组织的对照小鼠出现记忆问题，表明人类脑组织对动物认知产生了影响1。
Pașca团队对该技术的应用范围持谨慎态度。Pașca明确反对在灵长类动物上进行此类实验，表示"做这个实验在灵长类动物上是一条非常清晰的红线"1。去年Pașca召集伦理专家研究神经类器官技术的伦理含义，包括动物发展人类意识的可能性1。
Scientists at Stanford University led by neuroscientist Sergiu Pașca have successfully grown human brain tissue within mice, according to research published in Nature 1. The team used genetic engineering to remove the cerebral cortex and hippocampus from mice, then implanted human brain organoids into the resulting cavities 1. The procedure resulted in nearly half of the affected mice's brain volume being replaced by human cells 1.
The hybrid mice demonstrated improved cognitive performance compared to controls. Animals containing human brain tissue performed better on maze tests, while mice lacking the replacement tissue experienced memory problems 1.
Pașca emphasized important ethical boundaries for such work, stating that conducting these experiments in primates represents "a very clear red line" 1. Last year, Pașca convened ethics experts to examine the ethical implications of neural organoid technology, including the possibility of animals developing human consciousness 1.
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