一项汇总139项临床试验、涉及近10,000名患者的大规模分析表明，膝关节支架、水疗法和运动在缓解膝关节骨关节炎疼痛方面的效果可能超过许多高科技治疗手段。1这项由中国内江市第一人民医院研究者Yuan Luo领导的研究于2025年6月发表在开放获取期刊PLOS One上。1研究评估了12种非药物治疗方法，包括激光疗法、电刺激、膝关节支架、鞋垫、肌动学胶带、水疗法、运动和超声波等。1
在综合评估中，膝关节支架在减少疼痛、缓解僵硬和改善身体功能方面排名最高，水疗法则在减轻疼痛方面表现特别突出。1规律运动也被证明能持续改善患者的疼痛症状和身体功能。1相比之下，超声波治疗在所有比较方法中排名接近底部。1研究团队建议患者和临床医生优先选择这些循证治疗方案，而不是可能带来胃肠道和心血管风险的抗炎药物。1
A comprehensive analysis of 139 clinical trials involving nearly 10,000 patients has identified knee braces, water therapy, and exercise as potentially more effective than many high-tech interventions for treating knee osteoarthritis.1 The study, led by Yuan Luo at Neijiang First People's Hospital in China and published in the open-access journal PLOS One in June 2025, evaluated 12 different non-drug treatment methods including laser therapy, electrical stimulation, knee braces, shoe inserts, kinesiology tape, water therapy, exercise, and ultrasound.1
The research found that knee braces ranked highest for reducing pain and stiffness while improving physical function.1 Water therapy proved particularly effective for pain relief, while regular exercise demonstrated sustained improvements in both pain and physical function.1 By contrast, ultrasound treatment ranked near the bottom of the comparative analysis.1 The researchers concluded that "knee braces, water therapy, and exercise represent the most effective non-drug treatment approaches for knee osteoarthritis," recommending that patients and clinicians prioritize these evidence-based options over anti-inflammatory medications that may carry gastrointestinal and cardiovascular risks.1
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