研究人员利用生物学衰老时钟发现，通过机器灌注保存的捐献肝脏在分子水平上显示出生物年龄降低现象1。与传统冷冻保存方法相比，灌注肝脏的生物年龄下降约30%，尽管这些器官的实际年龄可能更大或状况更差1。
灌注过程通过在34摄氏度的条件下向器官泵入氧气和营养物质，实现了这种生物年龄的逆转1。研究分析了19个捐献肝脏的37个样本和103个捐献肝脏的208个样本1。
这一发现可能解释了为什么来自年轻捐献者的器官移植成功率更高，以及接受灌注器官的患者移植失败率更低1。灌注技术的成本在德国约为10,000欧元，在美国则为每个器官80,000至100,000美元1。研究人员表示，灌注技术在过去三年内已经完全改变了移植手术的格局1。
Researchers have discovered that donated livers preserved using machine perfusion show reduced biological age at the molecular level compared to those stored through conventional cold preservation 1. Analysis of samples from donated livers revealed that perfused organs exhibited approximately 30% lower biological aging, despite potentially being chronologically older or in worse condition than their cold-preserved counterparts 1.
The perfusion process works by pumping oxygen and nutrients through organs at 34 degrees, effectively reversing biological aging 1. This finding may explain why organs from younger donors typically achieve higher transplant success rates and why perfused organs experience lower post-transplant failure rates 1. The research analyzed 37 samples from 19 donated livers and 208 samples from 103 donated livers, utilizing biological aging clocks to assess molecular changes 1. According to Heidi Yeh, the perfusion technology has "completely transformed the landscape of transplant surgery" over the past three years 1. The procedure carries significant costs, ranging from approximately €10,000 in Germany to $80,000 to $100,000 per organ in the United States 1.
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