悉尼大学研究团队首次在人类中证实，心脏能够在心肌梗死后再生肌肉细胞，这一发现推翻了心脏受损区域无法修复的长期假设1。该研究由悉尼大学医学与健康学院的Robert Hume博士领导，医学科学学院心力衰竭专家Sean Lal教授担任资深作者，研究结果已发表在《循环研究》期刊2026年第138卷第2期上1。研究采用了世界首创的方法，从旁路手术患者的心脏活组织中采集样本，从而实现了这一重要发现1。
研究团队希望通过放大心脏的这一天然修复过程，开发新的心力衰竭治疗方法1。这项发现具有重要的临床意义，因为单次心肌梗死可以摧毁人类心脏三分之一的细胞1。澳大利亚数据显示，心血管疾病占该国死亡总数的24%，约144,000人患有心力衰竭，但每年仅进行约115例心脏移植1。
Researchers at the University of Sydney have made a groundbreaking discovery: the human heart can regenerate muscle cells following a myocardial infarction, overturning the longstanding assumption that damaged cardiac tissue cannot repair itself 1. The finding, published in Circulation Research in 2026 (Volume 138, Issue 2), represents the first confirmation in humans that cardiac muscle regeneration occurs after heart attack 1. Led by Dr. Robert Hume from the School of Medicine and Health, with senior researcher Professor Sean Lal, a heart failure cardiologist from the School of Medical Sciences, the team employed a world-first methodology by collecting tissue samples from the hearts of bypass surgery patients 1.
The implications of this research could transform treatment options for millions affected by cardiovascular disease. In Australia alone, approximately 144,000 people suffer from heart failure, yet only around 115 heart transplants are performed annually 1. A single heart attack can destroy up to one-third of the heart's cells 1. By understanding and amplifying this natural repair mechanism, researchers hope to develop new therapeutic approaches to combat heart failure. The work was conducted at the Baird Heart and Lung Applied Research Institute and Royal Prince Alfred Hospital in Sydney, addressing a critical gap in cardiac medicine where cardiovascular disease accounts for 24% of all deaths in Australia 1.
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