丹麦一项全国性研究发现，在2型糖尿病诊断后一年内开始使用他汀类药物的患者，其10年内痴呆症风险可降低15%。1该研究由欧洲心脏学会和哥本哈根大学医院开展，追踪了132585名未曾使用过他汀的2型糖尿病患者，这些患者的诊断时间跨越2006至2019年，随访至2021年。1在中位7.1年的随访期间，2.7%的参与者患上了痴呆症。1
研究结果表明，延迟开始他汀治疗（诊断后1至5年）的患者痴呆症风险降低幅度较小，为10%。1哥本哈根大学医院医生Tummas Ternhamar指出："他汀类药物似乎在2型糖尿病患者中使用不足，尽管其对心血管疾病有保护作用。"1研究结果表明早期他汀治疗可能具有超越心血管保护的额外益处。然而，研究人员强调这是一项观察性研究，不能证明他汀直接预防痴呆症。1
A nationwide Danish study has found that patients with type 2 diabetes who began taking statins within one year of diagnosis experienced a 15% reduction in dementia risk over a 10-year period 1. The research tracked 132,585 statin-naive type 2 diabetes patients diagnosed between 2006 and 2019, with follow-up extending through 2021 1. During a median follow-up period of 7.1 years, 2.7% of participants developed dementia 1.
The findings suggest that early statin intervention may offer protective benefits beyond cardiovascular health. Patients who delayed statin initiation until between one and five years after diagnosis showed a 10% reduction in dementia risk compared to those who never used statins 1. According to Doctor Tummas Ternhamar, "statins appear to be underutilized in type 2 diabetes patients, despite their protective effects against cardiovascular disease" 1. The researchers emphasized that this observational study cannot establish that statins directly prevent dementia 1.
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